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Hepatic complications of obesity.

Diehl AM

Division of Gastroenterology, Duke University Medical Center, Box 3256 Snyderman/GSRB-1, 595 LaSalle Street, Durham, NC 27710, USA. diehl004@mc.duke.edu

Obesity increases the risk and severity of liver disease. The most common form of liver disease that occurs in obesity is NAFLD. A better understanding of the basic disease mechanisms and natural histories ofNAFLD is needed to guide management and treatment of obese patients and others with this disorder. Large, prospective, randomized, controlled treatment trials also are needed. Ideally, such studies will focus on well-defined patient subsets and monitor the impact of therapy on clinically relevant endpoints, such as liver-related morbidity and mortality.

Published 12 April 2005 in Gastroenterol Clin North Am, 34(1): 45-61.
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