Liver Cirrhosis Research Today is a free monthly online journal that collates and summarizes the latest research about Liver Cirrhosis, including details on alcohol, treatment, drugs, effects, causes.

Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma.

Zindy P, Andrieux L, Bonnier D, Musso O, Langouët S, Campion JP, Turlin B, Clément B, Théret N

INSERM U620, Détoxication et Réparation Tissulaire, Facultés de Médecine et Pharmacie, Université de Rennes I, 2 Av. Léon Bernard, 35043 Rennes Cedex, France.

Phenotypic changes in injured livers involve complex network of genes whose interplays may lead to fibrosis and cirrhosis, a major risk of hepatocellular carcinoma. Gene expression profiles in fibrotic livers were analyzed by using cDNA microarray, hierarchical clustering and gene ontology. Analyses of a major cluster of upregulated genes in cirrhosis identified a new set of genes involved in DNA repair and damage. The upregulation of DNA repair genes was confirmed by real-time quantitative polymerase chain reaction and associated with necroinflammatory activity (P<0.001). Increased DNA repair activity in cirrhosis with inflammatory activity may reflect increased DNA damages as a consequence of chronic liver injury.

Published 28 December 2004 in FEBS Lett, 579(1): 95-9.
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